Chuang Liu, Xiangang Huang, Kok-Siong Chen, Sihan Xiong, Alexey V Yaremenko, Xueyan Zhen, Xinru You, Filippo Rossignoli, Yi Tang, Seyoung Koo, Wei Chen, Na Kong, Tian Xie, Khalid Shah, Wei Tao*. Systemic reprogramming of tumour immunity via IL-10-mRNA nanoparticles. Nature Nanotechnology (2025), 20, 1526–1538. 👀Full Paper👉 https://rdcu.be/eAcNi.
Chuang Liu#, Qiangqiang Shi#, Xiangang Huang, Seyoung Koo, Na Kong, Wei Tao. mRNA-based cancer therapeutics. Nature Reviews Cancer (2023), 23, 526–543. 👀Full Paper👉 https://rdcu.be/e1eXQ
Chuang Liu#, Alexey V. Yaremenko#, Xiaolong Li#, Xinru You, Xiaoyu Zhu, Nuo Liu, Wei Chen, Na Kong, Tian Xie, Gaurav D. Gaiha*, Robert Langer, and Wei Tao*. mRNA technology for the prevention and treatment of HIV-1 infection. Nature Reviews Bioengineering (2026), 4, 435–453. 👀Full Paper👉https://rdcu.be/e1eZT
Chuang Liu, Khalid Shah*. Taming CAR T cell therapy toxicity. Nature Materials (2023), 22, 1444–1445.
Sihan Xiong, Chuang Liu*. Breaking the PEG barrier to boost mRNA-LNP therapeutics. Nature Reviews Materials (2025), 10, 799–800.
Xiangang Huang#, Chuang Liu#, Na Kong, Yufen Xiao, Arif Yurdagul, Ira Tabas, Wei Tao*. Synthesis of siRNA nanoparticles to silence plaque-destabilizing gene in atherosclerotic lesional macrophages. Nature Protocols (2022), 17, 748–780.
Selected Publications by Years (*corresponding author)
2026
1. Chuang Liu#, Alexey V. Yaremenko#, Xiaolong Li#, Xinru You, Xiaoyu Zhu, Nuo Liu, Wei Chen, Na Kong, Tian Xie, Gaurav D. Gaiha*, Robert Langer, and Wei Tao*. mRNA technology for the prevention and treatment of HIV-1 infection. Nature Reviews Bioengineering (2026), 4, 435–453. 👀Full Paper👉https://rdcu.be/e1eZT
2. Jun Liao, Zhiqiang Lin*, Chuang Liu*. Precision Uterine mRNA Therapy to Restore Implantation and Fertility. Materials Today (2026), 95, 103270.
3. Jun Liao, Zhiqiang Lin*, Chuang Liu*. Programming Extracellular Protein Fate With Peptide Chimeras. Chem (2026), 12, 5, 103040.
4. Karel Lee Wen Xuan, Ángel Luis Barreto Muñoz, Jong Seung Kim*, Jing Zhang*, Chuang Liu*. Gut microbiota writes the clearance code for in vivo delivery systems. Matter (2026), 9, 7, 102901.
2025
1. Chuang Liu, Xiangang Huang, Kok-Siong Chen, Sihan Xiong, Alexey V Yaremenko, Xueyan Zhen, Xinru You, Filippo Rossignoli, Yi Tang, Seyoung Koo, Wei Chen, Na Kong, Tian Xie, Khalid Shah, Wei Tao*. Systemic reprogramming of tumour immunity via IL-10-mRNA nanoparticles. Nature Nanotechnology (2025), 20, 1526–1538. 👀Full Paper: https://rdcu.be/eAcNi. 👉Highlighted by「Min.News」「Bioon.com」
4. Xiangang Huang, Chuang Liu, Shonit Nair Sharma, Xinru You, Shuying Chen, Yongjiang Li, Hai-Jun Liu, Bin Liu, Qimanguli Saiding, Wei Chen, Yuhan Lee, Na Kong, Reza Abdi, Wei Tao*. Oral delivery of liquid mRNA therapeutics by an engineered capsule for treatment of preclinical intestinal disease. Science Translational Medicine(2025), 17,eadu1493.
5. Sihan Xiong, Chuang Liu*. Breaking the PEG barrier to boost mRNA-LNP therapeutics. Nature Reviews Materials (2025), 10, 799–800.
6. Alexey V. Yaremenko*, Nadezhda A. Pechnikova, Chuang Liu*. Advancing Lung Cancer Treatment: mRNA Therapeutics and Delivery Strategies. Nano Letters (2025).https://doi.org/10.1021/acs.nanolett.5c03826
2024
1. Nadezhda A Pechnikova*, Amalia Aggeli, Anastasiia A Latypova, Aleksandra V Iaremenko, Kalliopi Domvri, Ilya V Zubarev, Chuang Liu*, Alexey V Yaremenko*. Implantable Biomaterials for Cancer Immunotherapies. Advanced Functional Materials (2025), 35, 2416813.
1. Chuang Liu, Khalid Shah*. Taming CAR T cell therapy toxicity. Nature Materials (2023), 22, 1444–1445.
2. Chuang Liu#, Qiangqiang Shi#, Xiangang Huang, Seyoung Koo, Na Kong*, Wei Tao*. mRNA-based cancer therapeutics. Nature Reviews Cancer (2023), 23, 526–543. 👀Full paper👉 https://rdcu.be/e1eXQ「Highlighted in the “Nobel Prize in Physiology or Medicine 2023” Collection; Web of Science Hot | Highly Cited Paper」
3. Wei Chen#, Yongjiang Li#, Chuang Liu#, Yong Kang, Duotian Qin, Shuying Chen, Jun Zhou, Hai‐Jun Liu, Bijan Emiliano Ferdows, Dylan Neal Patel, Xiangang Huang, Seyoung Koo, Na Kong, Xiaoyuan Ji, Yihai Cao, Wei Tao*, Tian Xie*. In situ Engineering of Tumor‐Associated Macrophages via a Nanodrug‐Delivering‐Drug (β‐Elemene@Stanene) Strategy for Enhanced Cancer Chemo‐Immunotherapy. Angewandte Chemie International Edition (2023), 62, e202308413.
2022
1. Xiangang Huang#, Chuang Liu#, Na Kong, Yufen Xiao, Arif Yurdagul, Ira Tabas, Wei Tao*. Synthesis of siRNA nanoparticles to silence plaque-destabilizing gene in atherosclerotic lesional macrophages. Nature Protocols (2022), 17, 748–780.
2. Zhongyang Zhang#, Jun Zhou#, Chuang Liu#, Jiaming Zhang, Yo Shibata, Na Kong, Claudia Corbo*, Mitchel B Harris*, Wei Tao*. Emerging biomimetic nanotechnology in orthopedic diseases: progress, challenges, and opportunities. Trends in Chemistry (2022), 4, 5, 420-436.
2021
1. Wen Pan#, Chuang Liu#, Yunhui Li*, Yang Yang, Wenliang Li, Chan Feng*, Leijiao Li*. Ultrathin tellurium nanosheets for simultaneous cancer thermo-chemotherapy. Bioactive Materials (2021), 13, 96-104.
2. Chuang Liu#, Shan Sun#, Qiang Feng#, Gongwei Wu, Yiting Wu, Na Kong, Zhangsen Yu, Junlie Yao, Xingcai Zhang, Wei Chen, Zhongmin Tang, Yufen Xiao, Xiangang Huang, Aman Lv, Chenyang Yao, Haibo Cheng, Aiguo Wu*, Tian Xie*, Wei Tao*. Arsenene Nanodots with Selective Killing Effects and their Low‐Dose Combination with ß‐Elemene for Cancer Therapy. Advanced Materials (2021), 33, 2102054.
3. Wei Chen#, Chuang Liu#, Xiaoyuan Ji, John Joseph, Zhongmin Tang, Jiang Ouyang, Yufen Xiao, Na Kong, Nitin Joshi, Omid C Farokhzad*, Wei Tao*, Tian Xie*. Stanene‐Based Nanosheets for β‐Elemene Delivery and Ultrasound‐Mediated Combination Cancer Therapy. Angewandte Chemie International Edition (2021), 60, 7155.
4. Chuang Liu#, Jinwoo Shin#, Subin Son#, Youmi Choe#, Nika Farokhzad, Zhongmin Tang, Yufen Xiao, Na Kong*, Tian Xie*, Jong Seung Kim*, Wei Tao*. Pnictogens in medicinal chemistry: evolution from erstwhile drugs to emerging layered photonic nanomedicine. Chemical Society Reviews (2021), 50, 2260-2279.
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